In 1992 in elliptical El Paso, TX a randomized, double-blind, placebo controlled study of subjects (n=130) with allergic rhinitis in 1992-1993 was conducted. The average IgE level of the placebo treated subjects remained essentially flat, crosstrainer while the average IgE level for active treated subjects was reduced significantly from baseline to Day 30.7 In 1993 in El Paso, TX, valid subjects (n=66) returned elliptical a second set of symptom diaries which they had completed for days 365 to 395 (the same period, one year after the first set of symptom crosstrainer diaries). The active group had mean symptom scores showing statistically significant decreases from 1992 to 1993. The placebo elliptical group had increased crosstrainer symptoms in 1993. (The elliptical relevant crosstrainer pollen counts at the study site in 1993 were much higher than in 1992, leading to expectation of higher symptoms.)7

Studies indicate that ingested oral cyanocobalamin tablets are ineffective in the treatment of allergic disease, perhaps because once elliptical ingested, they are directly metabolized in the liver. When B12 is delivered via injection or lozenge it passes throughout the bloodstream before arriving at the liver. It is during this first pass in its native form crosstrainer that it is believed to exert its therapeutic effect. CLINICAL RESEARCH: "The World Health Organization (WHO) recognizes allergic rhinitis (hay fever), sinusitis, asthma,...conjunctivitis, urticaria, eczema, dermatitis (contact and atopic)...allergic elliptical and migraine headache...as diseases in which IgE-mediated allergy may be involved."1 In 1988, asthma crosstrainer and allergic elliptical rhinitis subjects were treated with B12. Total IgE, specific IgE and pulmonary lung functions were taken at days 45, 150 and 180 from baseline. Eight of the 9 subjects had reduced IgE. 2 In 1989 open label studies at two sites in crosstrainer Riverside County, CA in 1989. elliptical Sixteen of the 17 subjects had lowered crosstrainer and elliptical IgE levels crosstrainer from Day 0 to Day 30.3